When Anakin gives Padmé his lightsaber in "Hostage Crisis" to prove his love for her, he does so in such a way that, if it were activated, the blade would impale her:
To some degree, this foreshadows the events of Revenge of the Sith where Anakin's turn to the dark side causes Padmé to lose her will to live. Here, he comes very close to injuring her fatally.
